+ 44 (0) 1709 361 241 info@kirkstall.com

Published Paper: In Vitro Toxicological Screening of Primary Human Endothelial Cells

In Vitro Toxicological Screening of Nanoparticles on Primary Human Endothelial Cells and the Role of Flow in Modulating Cell Response

Abstract

After passage through biological barriers, nanomaterials inevitably end up in contact with the vascular endothelium and can induce cardiovascular damage. In this study the toxicity and sub-lethal effects of six types of nanoparticle, including four of industrial and biomedical importance, on human endothelial cells were investigated using different in vitro assays.

The results show that all the particles investigated induce some level of damage to the cells and that silver particles were most toxic, followed by titanium dioxide. Furthermore, endothelial cells were shown to be more susceptible when exposed to silver nanoparticles under flow conditions in a bioreactor.

The study underlines that although simple in vitro tests are useful to screen compounds and to identify the type of effect induced on cells, they may not be sufficient to define safe exposure limits. Therefore, once initial toxicity screening has been conducted on nanomaterials, it is necessary to develop more physiologically relevant in vitro models to better understand how nanomaterials can impact on human health.

 

Link to full paper: Taylor and Francis Online

If you would like to read other published papers using Quasi Vivo please see our click here.

Quasi Vivo®, commercially available and used in 70+ labs worldwide, getting started is easy and cost effective!

Contact Us

Kirkstall Ltd
3 Aspen Court
Centurion Business Park
Templeborough
Rotherham
S60 1FB

+ 44 (0) 1709 361 241
info@kirkstall.com

Products

QV500

QV600

QV900